松弛素及其相关肽

       　近来，在松弛肽及其相关肽的研究领域取得了不少重要进展。例如，一些新型的松弛肽相继被发现，一些松弛肽的受体也被鉴定出来， 对他们的构效关系已经获得到了一些认识。借助于动物模型，松弛肽的某些生理作用也得到认识。现在人们已知，松弛肽的作用不仅包括 再生过程，也包括许多的非再生过程。这其中的一些发现具有临床应用潜力，目前研究者们正借助于人类疾病的生物学模型来开拓松弛肽的 临床应用。因此CMBI特搜集了关于松弛素及其相关肽 的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。

Part I. Structure/Activity Aspects of Relaxin, Relaxin-Related Peptides, and Their Receptors:
• Relaxin Research in the Postgenomic Era
• Characterization of the Mouse and Rat Relaxin Receptors
• Characterization of the Rat INSL3 Receptor
• Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors
• LGR7-Truncate Is a Splice Variant of the Relaxin Receptor LGR7 and Is a Relaxin Antagonist in Vitro
• The Human LGR7 Low-Density Lipoprotein Class A Module Requires Calcium for Structure
• Studies on Soluble Ectodomain Proteins of Relaxin (LGR7) and Insulin 3 (LGR8) Receptors
• The Chemistry and Biology of Human Relaxin-3
• Recent Progress in Relaxin-3-Related Research
• Receptors for Relaxin Family Peptides
• Expression of Porcine Prorelaxin in Transgenic Tobacco

 

Part IIA. Actions of Relaxin: Reproductive Tissues during Pregnancy:

• Genetic Targeting of Relaxin and Insl3 Signaling in Mice
• Mechanisms of Relaxin Action in the Reproductive Tract
• Oxytocin and Estrogen Receptor Expression in the Myometrium of Pregnant Relaxin-Deficient (Rlx––) Mice
• Relaxin Regulates Endometrial Structure and Function in the Rhesus Monkey
• Effects of the Sucking Stimulus on Relaxin Receptor (LGR7) Expression in the Mammary Apparatus of the Tammar Wallaby (Macropus eugenii)
• Potential Binding Sites for Relaxin in Pregnant Rabbits

 

Part IIB. Actions of Relaxin: Reproductive Tissues in Nonpregnant Animals:
• Porcine and Human Relaxin Bioactivity
• Tissue-Specific Effects of Relaxin on the Reproductive Tract of Neonatal Gilts
• Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle
• Relaxin-Induced Angiogenesis in Ovary Contributes to Follicle Development

 

Part IIIA. Actions of Relaxin in Nonreproductive Tissues: Hemodynamic, Osmoregulatory, and Antifibrotic:
• Role of Relaxin in Maternal Renal Vasodilation of Pregnancy
  
• Recombinant Human Relaxin (rhRLX) Modifies Systemic Arterial Properties in Conscious Rats Irrespective of Gender, but in a Biphasic Fashion
  
• Renal Hemodynamic Effects of Relaxin in Humans
  
• The Relaxin Gene-Knockout Mouse
  
• Relaxin Regulates Collagen Overproduction Associated with Experimental Progressive Renal Fibrosis
  
• Relaxin Receptor Expression in Hepatic Stellate Cells and in Cirrhotic Rat Liver Tissue
• Relaxin Modulates Fibroblast Function, Collagen Production, and Matrix Metalloproteinase-2 Expression by Cardiac Fibroblasts
  
• Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease
  

   

  Part IIIB. Actions of Relaxin in Nonreproductive Tissues:Central Actions:
• Localization of LGR7 (Relaxin Receptor) mRNA and Protein in Rat Forebrain
• Localization of LGR7 Gene Expression in Adult Mouse Brain Using LGR7 Knock-outLacZ Knock-in Mice Correlation with LGR7 mRNA Distribution
• Insulin-Relaxin Family Peptide Signaling and Receptors in Mouse Brain Membranes and Neuronal Cells
• Central Effects of Long-Term Relaxin Expression in the Rat
• Relaxin Pretreatment Decreases Infarct Size in Male Rats after Middle Cerebral Artery Occlusion
• Relaxin Inhibits Central Angiotensin II Expression in Killifish

 

Part IVA. Relaxin-Induced Signal Transduction: Interaction of Relaxin and Steroid Signaling:
• New Insight into the Transcriptional Regulation of Vascular Endothelial Growth Factor Expression in the Endometrium by Estrogen and Relaxin
• Effects of Relaxin on Neonatal Porcine Uterine Growth and Development
• The Pregnancy Hormone Relaxin Binds to and Activates the Human Glucocorticoid Receptor

 

Part IVB. Relaxin-Induced Signal Transduction: Relaxin Stimulates Multiple Signal Transduction Pathways:
• Relaxin Stimulates Multiple Signaling Pathways
• Relaxin Signaling from Natural Receptors
• Signal Switching after Stimulation of LGR7 Receptors by Human Relaxin 2
• Signaling Pathways of the LGR7 and LGR8 Receptors Determined by Reporter Genes
• Relaxin Stimulates cAMP Production in MCF-7 Cells upon Overexpression of Type V Adenylyl Cyclase
• Pathways Used by Relaxin to Regulate Myometrial Phospholipase C
• A Novel, Adenylate Cyclase, Signaling Mechanism of Relaxin H2 Action
• Relaxin Restores Altered Ileal Spontaneous Contractions in Dystrophic (mdx) Mice
• Effects of Relaxin on Vascular Smooth Muscle and Endothelial Cells in Normotensive and Hypertensive Rats
• Relaxin Induces Matrix Metalloproteinase-9 through Activation of Nuclear Factor Kappa B in Human THP-1 Cells
• Does Human Relaxin-2 Affect Peripheral Blood Mononuclear Cells to Increase Inflammatory Mediators in Pathologic Bone Loss
• Is Relaxin a Calcium TransporterBuffer
• Responses of GPCR135 to Human Gene 3 (H3) Relaxin in CHO-K1 Cells Determined by Microphysiometry

 

Part VA. Clinical Aspects of Relaxin: Pregnancy:
• Human Decidual Relaxin and Preterm Birth
• Mechanisms of Relaxin-Mediated Premature Birth
• Clinical Use of Relaxin to Facilitate Birth
• Relaxin Concentrations in Serum and Urine of Endangered Species

 

Part VB. Clinical Aspects of Relaxin: Connective Tissue:
• Use of Relaxin in Orthodontics
• Does Human Relaxin Accelerate Orthodontic Tooth Movement in Rats
• The Use of Relaxin Improves Healing in Injured Muscle
• Photonic Monitoring in Real Time of Vascular Endothelial Growth Factor Receptor 2 Gene Expression under Relaxin-Induced Conditions in a Novel Murine Wound Model
• Relaxin of Prostatic Origin Might Be Linked to Perineal Hernia Formation in Dogs

 

Part VC. Clinical Aspects of Relaxin: Ischemia/Allergic Response/Cancer:
• Basic Progress and Future Therapeutic Perspectives of Relaxin in Ischemic Heart Disease
• Human Recombinant Relaxin Reduces Heart Injury and Improves Ventricular Performance in a Swine Model of Acute Myocardial Infarction
• Relaxin as an Additional Protective Substance in Preserving and Reperfusion Solution for Liver Transplantation, Shown in a Model of Isolated Perfused Rat Liver
• Myocardial Relaxin Counteracts Hypertrophy in Hypertensive Rats
• Relaxin Favors the Morphofunctional Integration between Skeletal Myoblasts and Adult Cardiomyocytes in Coculture
• Relaxin Adenylyl Cyclase System of Pregnant Women with Diabetes
• Human Medullary Thyroid Carcinoma
• Relaxin Downregulates the Calcium Binding Protein S100A4 in MDA-MB-231 Human Breast Cancer Cells
• Relaxin Does Not Influence the Growth of Human Cervical Adenocarcinoma (HeLa) Cells in Culture
• Effects of Relaxin in a Model of Rat Adjuvant-Induced Arthritis

 

Part VI. Physiologic Roles of INSL3:
• Insulin-Like Factor 3 A Novel Circulating Hormone of Testicular Origin in Humans
• Insulin-Like Factor 3
• Immunohistochemical Localization of Relaxin-Like FactorInsulin-Like Peptide-3 in the Bovine Corpus Luteum
• Restricted Expression of LGR8 in Intralaminar Thalamic Nuclei of Rat Brain Suggests a Role in Sensorimotor Systems
• Detection, Localization, and Action of the INSL3 Receptor, LGR8, in Rat Kidney

 

Part VII. Evolution of Signaling Systems in Relaxin Family Peptides:
• Evolution of the Relaxin-Like Peptide Family
• Evolution of the Signaling System in Relaxin-Family Peptides
• Coevolution of the Relaxin-Like Peptides and Their Receptors