Epigenetics and human disease

       　表观遗传是指DNA序列不发生变化但基因表达却发生了可遗传的改变，即基因型未发生变化而表型却发生了改变。异常的表观遗传可能导致发生肿瘤、自身免疫性疾病、衰老、 神经精神异常和多种儿科综合征。表观遗传学主要是对染色质重塑、DNA甲基化及组蛋白修饰、X染色体失活、非编码RNA调控等多方面进行研究。对表观遗传中各种因子的突变导致的疾病的研究将有助我们了解表观遗传机制、基因表达和环境之间的关系，并期望能纠正或降低那些能够导致疾病的表观基因的不稳定性，指导疾病的诊治和新药的研制。为此CMBI特准备了关于Epigenetics and human disease的特别报道，供实践参考。更多文献，请用相关关键词通过CMBI文献查询获取。

• The Role of Methylation in the Mechanism of Action of Tumor Suppressor Genes
  
• Sensitive Detection of DNA Methylation
  
• Cancer Biomarker Validation
  
• Genome-Wide Analysis of Epigenetics in Cancer
  
• Epigenetics in human disease
  
• Epigenetics and human disease
  
• Early detection and risk assessment-proceedings and recommendations from the Workshop on Epigenetics in Cancer Prevention
  
• DNA methylation 40 years later
  
• Zebularine-a candidate for epigenetic cancer therapy
  
• Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease
  
• The role of epigenetic inactivation of 14-3-3 in human cancer
  
• The epigenetic progenitor origin of human cancer
  
• The clinical application of targeting cancer through histone acetylation and hypomethylation
  
• stem cells and epigenesis in cancer
  
• Stem cell consequences of embryo epigenetic defects
  
• Role of epigenetic changes in hematological malignancies
  
• Nutritional epigenetics
  
• Histone modifications as a platform for cancer therapy
  
• Epigenetics and the germline
  
• Epigenetics and the Environment
  
• Epigenetics and cancer
  
• Epigenetics and airways disease
  
• Epigenetic regulation by histone methylation and histone variants
  
• Epigenetic mechanisms of tumorigenesis
  
• Epigenetic changes in virus-associated human cancers
  
• Epigenetic changes in prostate cancer
  
• Epigenetic alterations in gastric carcinogenesis
  
• DNA methylation, genomic silencing, and links to nutrition and cancer
  
• DNA methylation and epigenotypes
  
• Diagnostic and therapeutic applications of epigenetics
  
• Clinical translation of epigenetics in cancer
  
• Cancer epigenetics
  
• Advances in chromatin remodeling and human disease
  
• A blueprint for a Human Epigenome Project
  
• The epigenetic network regulating muscle development and regeneration
  
• Methylation-lost in hydroxylation
  
• Histone Lysine Demethylases and Their Impact on Epigenetics
  
• Quantitative DNA Methylation Analysis
  
• Quantitative assessment of DNA methylation-potential applications for disease diagnosis, classification, and prognosis in clinical settings
  
• Inherited epigenetic variation — revisiting soft inheritance
  
• Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors
  
• Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
  
• X marks the spot
  
• Transcription — guarding the genome by sensing DNA damage
  
• The theoretical basis of transcriptional therapy of cancer
  
• the promise of epigenetic therapy
  
• The prima donna of epigenetics-the regulation of gene expression by DNA methylation
  
• The power and the promise of DNA methylation markers
  
• The history of cancer epigenetics
  
• The fundamental role of epigenetic events in cancer
  
• The epigenome as a molecular marker and target
  
• Targeted modulation of MGMT
  
• Silent transmission
  
• Repairing DNA-methylation damage
  
• Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma
  
• On the biological significance of DNA methylation
  
• MGMT-its role in cancer aetiology and cancer therapeutics
  
• Methylation of the tumor suppressor gene RASSF1A in human tumors
  
• Methyl-CpG-binding proteins in cancer
  
• Inhibitors of DNA methylation
  
• Genomic DNA methylation
  
• Gene-promoter hypermethylation as a biomarker in lung cancer
  
• Folate and prevention of colorectal cancer
  
• Epigenetics provides a new generation of oncogenes and tumour-suppressor genes
  
• epigenetics makes the difference
  
• Epigenetic silencing of the MGMT gene in cancer
  
• Epigenetic mechanisms of tumorigenesis
  
• Epigenetic mechanisms in memory formation
  
• Epigenetic events in the colorectum and in colon cancer
  
• Enzymatic DNA methylation is an epigenetic control for genetic functions of the cell
  
• DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
  
• DNA methylation-its role in lung carcinogenesis and therapeutic implications
  
• DNA methylation in neuroblastic tumors
  
• DNA methylation disturbances as novel therapeutic target in lung cancer
  
• DNA methylation and human disease
  
• DNA methylation and gene silencing in cancer
  
• DNA methylation and demethylation as targets for anticancer therapy
  
• DNA demethylation and carcinogenesis
  
• Detection and interpretation of altered methylation patterns in cancer cells
  
• CpG island methylator phenotype in cancer
  
• CpG island hypermethylation in progression of esophageal and gastric cancer
  
• Combined targeting of the epigenetic silence in leukemia
  
• Chromatin modifier enzymes, the histone code and cancer
  
• Causes and consequences of DNA hypomethylation in human cancer
  
• Aberrant methylation of H-cadherin (CDH13) promoter is associated with tumor progression in primary nonsmall cell lung carcinoma
  
• DNA methylation
  
• Epigenetic therapy of cancer
  
• Epigenetics of cervical cancer. An overview and therapeutic perspectives
  
• Loss of Imprinting of IGF2-A Common Epigenetic Modifier of Intestinal Tumor Risk