内皮素研究进展

       　内皮素（endothelin，ET）自1988年发现以来，一直是人们研究的热点。它不仅存在于血管内皮，也广泛存在于各种组织和细胞中，是调节心血管功能的重要因子， 对维持基础血管张力与心血管系统稳态起重要作用。内皮素（ET-1）是迄今为止发现的作用最强的缩血管物质。其引起的血管收缩、心肌缺血、代谢紊乱和细胞增殖是与血管损伤有关疾病的共同致病因素。鉴于内皮素研究的重要性，CMBI特将最新的关于内皮素研究进展的文献集结成辑，供研究参考。我们曾在126期做过相关报导。更多的文献资料，请用相关关键词通过CMBI文献查询获取。

• Novel aspects of endothelium-dependent regulation of vascular tone
  
• Endothelin receptor antagonists
  
• Cardiovascular endothelins-Essential regulators of cardiovascular homeostasis
  
• Polymorphism in Endothelin-Related Genes Limits Exercise-Induced Decreases in Arterial Stiffness in Older Subjects.
  
• Increased Expression of Cyclooxygenase-2 Mediates Enhanced Contraction to Endothelin ETA Receptor Stimulation in Endothelial Nitric Oxide Synthase Knockout Mice.
  
• Endothelin B Receptor Antagonist Increases Preproendothelin-1 Transcription in Bovine Aortic Endothelial Cells and In Vivo.
  
• Fifteen years of Endothelin
  
• The endothelin system in pulmonary hypertension
  
• The endothelin system and its role in acute myocardial infarction
  
• Synthesis and degradation of endothelin-1
  
• Role of ET-1 in the regulation of coronary circulation
  
• Role of endothelins in septic, cardiogenic, and hemorrhagic shock
  
• Role of endothelins in congestive heart failure
  
• Role of endothelins in animal models of hypertension
  
• Role of endothelin in regulation of resistance, fluid-exchange, and capacitance functions of the systemic circulation
  
• Role of endothelin in human hypertension
  
• Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism
  
• Endothelins in chronic diabetic complications
  
• Endothelin-1 in chronic renal failure and hypertension
  
• Endothelin-1 in atherosclerosis and other vasculopathies
  
• Endothelin in the perinatal circulation
  
• Activation of sarcolemma and nuclear membranes ET-1 receptors regulates transcellular calcium levels
  
• Enhanced Endothelium-dependent Vasodilatation by Dual Endothelin Receptor Blockade in Individuals With Insulin Resistance
  
• Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic
  
• Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor-[alpha] Dependence on c-Jun N-Terminal Kinase
  
• Leptin Regulates Cardiomyocyte Contractile Function Through Endothelin-1 Receptor-NADPH Oxidase Pathway
  
• Downregulation of Endothelin-1 by Farnesoid X Receptor in Vascular Endothelial Cells
  
• A Role for p38 Mitogen-Activated Protein Kinase and c-Myc in Endothelin-Dependent Rat Aortic Smooth Muscle Cell Proliferation
  
• Pomegranate Flower Extract Diminishes Cardiac Fibrosis in Zucker Diabetic Fatty Rats
  
• Pharmacological Efficacy of CPU 86017 on Hypoxic Pulmonary Hypertension in Rats
  
• Flow-Independent Myocardial Ischemia Induced by Endothelin-1
  
• Effect of BQ-123, an Endothelin Antagonist, on Renal Hemodynamics, Tubular Function, Vasoactive Hormones, and Blood Pressure in Healthy Humans
  
• Blood Pressure Responses of Endothelin-11-31 Within the Rostral Ventrolateral Medulla Through Conversion to Endothelin-11-21
  
• roles of nitric oxide and endothelin-1 in delayed cerebral vasospasm
  
• Extrarenal ETB Plays a Significant Role in Controlling Cardiovascular Responses to High Dietary Sodium in Rats
  
• Exaggerated coronary vasoreactivity to endothelin-1 in aged rats
  
• Endothelin-1 Inhibits Inward Rectifier K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells Through Protein Kinase C
  
• Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition
  
• Endothelin Receptor Antagonists
  
• Endothelin antagonism in pulmonary hypertension, heart failure, and beyond
  
• Decrease of Endothelin Receptor Subtype ETB and Release of COX-Derived Products Contribute to Endothelial Dysfunction of Porcine Epicardial Coronary Arteries in Left Ventricular Hypertrophy
  
• comparison of endothelin A and endothelin A-B receptor blockade in heart failure
  
• Neural mechanisms-A polymorphism in the endothelin-A receptor gene is linked to baroreflex sensitivity.
  
• Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
  
• Glibenclamide Reveals Role for Endothelin in Hypoxia-Induced Vasoconstriction in Rat Intrapulmonary Arteries.
  
• Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
  
• Endothelin-1-Induced Arrhythmogenic Ca2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP3)-Receptor Type 2-Deficient Mice.
  
• Endothelin isoforms and the response to myocardial stretch
  
• Polymorphisms in Genes of the Endothelin System and Cerebral Small-Vessel Disease
  
• Increased circulating big endothelin-1, endothelin-1 and atrial natriuretic peptide in infants and children with heart failure secondary to congenital heart disease
  
• Endothelin-1 increases intracellular Ca2+ in rabbit pulmonary artery smooth muscle cells through phospholipase C
  
• Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats
  
• Role of Endothelin in Mediating Tumor Necrosis Factor-Induced Hypertension in Pregnant Rats
  
• Release of endothelin-1 from human endocardium after radiofrequency catheter ablation and coronary angioplasty
  
• Peroxisome Proliferator-Activated Receptor-Activation Reduces Salt-Dependent Hypertension During Chronic Endothelin B Receptor Blockade
  
• Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function
  
• Endothelin-1, via ETA Receptor and Independently of Transforming Growth Factor,, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells
  
• Endothelin-1 (1-31) Is an Intermediate in the Production of Endothelin-1 After Big Endothelin-1 Administration In Vivo
  
• Endothelin-1 in Congenital Heart Disease
  
• Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats
  
• Direct comparison of selective endothelin A and non-selective endothelin AB receptor blockade in chronic heart failure
  
• Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor-Deficient Rats
  
• Endothelin antagonism in pulmonary hypertension, heart failure, and beyond