动脉粥样硬化的研究近展



动脉粥样硬化的研究近展
动脉粥样硬化（atherosclerosis）是一组称为动脉硬化的血管病中最常见、最重要的一种。动脉粥样硬化的发病机理至今尚未完全明了，主要学说有：１、脂源性学说；２、致突变学说；３、损伤应答学说；４、炎症免疫学说；５、受体缺失学说；6、血栓形成学说。各种学说从不同角度探讨了动脉粥样硬化发生的可能机制，但无论哪种学说都不可能完全解释动脉粥样硬化发生发展过程中所有的细节和现象。动脉粥样硬化的发生机制相当复杂，可能是多种因素共同作用的结果。在上述几种学说中，近年来研究较多的是“损伤应答学说和炎症免疫学说”。众所周知，内皮损伤和动脉平滑肌细胞的增生是动脉粥样硬化形态学主要特征之一，在动脉粥样硬化发生中起关键作用。以前我们曾在33、71期做过相关报导。为此CMBI特准备了关于动脉粥样硬化的研究近展的特别报道，供实践参考。更多文献，请用相关关键词通过CMBI文献查询获取。
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Activation With Pioglitazone Improves Endothelium-Dependent Dilation in Nondiabetic Patients With Major Cardiovascular Risk Factors Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts Implications for End-Stage Valvular Heart Disease OxLDL-IgG Immune Complexes Induce Survival of Human Monocytes Oxidative Enzymopathies and Vascular Disease Mycophenolate mofetil (MMF) Mitral and Aortic Annular Calcification Are Highly Associated With Systemic Calcified Atherosclerosis Metformin Inhibits Proinflammatory Responses and Nuclear Factor-[kappa]B in Human Vascular Wall Cells Mechanisms of Disease atherosclerosis in autoimmune diseases Vascular Function and Mild Renal Impairment in Stable Coronary Artery Disease Uremia-Specific Effects in the Arterial Media During Development of Uremic Atherosclerosis in Apolipoprotein E-Deficient Mice Toll-Like Receptor 4-Dependent and-Independent Cytokine Secretion Induced by Minimally Oxidized Low-Density Lipoprotein in Macrophages The Proatherogenic Role of T Cells Requires Cell Division and Is Dependent on the Stage of the Disease The Apolipoprotein BAI Ratio and the Metabolic Syndrome Independently Predict Risk for Myocardial Infarction in Middle-Aged Men Socioeconomic Differences in Progression of Carotid Intima-Media Thickness in the Atherosclerosis Risk in Communities Study Serum Lipoprotein Lipase Concentration and Risk for Future Coronary Artery Disease Role of the Estrogen and Progestin in Hormonal Replacement Therapy on Apolipoprotein A-I Kinetics in Postmenopausal Women Repopulation of Apolipoprotein E Knockout Mice With CCR2-Deficient Bone Marrow Progenitor Cells Does Not Inhibit Ongoing Atherosclerotic Lesion Development Relative Contributions of ABCA1 and SR-BI to Cholesterol Efflux to Serum From Fibroblasts and Macrophages Phenotypic Modulation of Intima and Media Smooth Muscle Cells in Fatal Cases of Coronary Artery Lesion Lipoprotein-Associated Phospholipase A2 and Measures of Extracoronary Atherosclerosis Leukocyte Transglutaminase 2 Expression Limits Atherosclerotic Lesion Size Lesional Overexpression of Matrix Metalloproteinase-9 Promotes Intraplaque Hemorrhage in Advanced Lesions But Not at Earlier Stages of Atherogenesis Increased Apolipoprotein Deposits in Early Atherosclerotic Lesions Distinguish Symptomatic From Asymptomatic Patients Identification of the cAMP-Responsive Enhancer of the Murine ABCA1 Gene Identification of Macrophage Arginase I as a New Candidate Gene of Atherosclerosis Resistance Expression Profiling Identifies Smooth Muscle Cell Diversity Within Human Intima and Plaque Fibrous Cap Evidence for a Gene Influencing High-Density Lipoprotein Cholesterol on Chromosome 4q31.21 Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function Elevated Markers of Endothelial Dysfunction Predict Type 2 Diabetes Mellitus in Middle-Aged Men and Women From the General Population Effects of Rosiglitazone on Lipids, Adipokines, and Inflammatory Markers in Nondiabetic Patients With Low High-Density Lipoprotein Cholesterol and Metabolic Syndrome Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E-Low-Density Lipoprotein-Double Knockout Mice Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease Apolipoproteins C-III and A-V as Predictors of Very-Low-Density Lipoprotein Triglyceride and Apolipoprotein B-100 Kinetics Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I A novel nonsense apolipoprotein A-I mutation (apoA-IE136X) causes low HDL cholesterol in French Canadians Increased Aortic Intima-Media Thickness in 11-Year-Old Healthy Children With Persistent Chlamydia pneumoniae Seropositivity Impact of HIV and highly active antiretroviral therapy on leukocyte adhesion molecules, arterial inflammation, dyslipidemia, and atherosclerosis Hepatic Lipase Deficiency Delays Atherosclerosis, Myocardial Infarction, and Cardiac Dysfunction and Extends Lifespan in SR-BIApolipoprotein E Double Knockout Mice Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells Effects of omega-3 fatty acids on coronary restenosis, intima–media thickness, and exercise tolerance-A systematic review Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia Effect of Intensive Versus Standard Lipid-Lowering Treatment With Atorvastatin on the Progression of Calcified Coronary Atherosclerosis Over 12 Months Early Growth Response-1 in Cardiovascular Pathobiology Differences in Vascular Bed Disease Susceptibility Reflect Differences in Gene Expression Response to Atherogenic Stimuli Diet and Murine Atherosclerosis Common hepatic lipase gene promoter variant predicts the degree of neointima formation after carotid endarterectomy Combined Effects of Hemoglobin A1c and C-Reactive Protein on the Progression of Subclinical Carotid Atherosclerosis Cigarette smoking, regular exercise, and peripheral blood flow Cholestanol-A serum marker to guide LDL cholesterol-lowering therapy C-type natriuretic peptide (CNP) suppresses plasminogen activator inhibitor-1 (PAI-1) in vivo Atorvastatin Reduces the Expression of Prostaglandin E2 Receptors in Human Carotid Atherosclerotic Plaques and Monocytic Cells Atherosclerosis Susceptibility Loci Identified From a Strain Intercross of Apolipoprotein E-Deficient Mice via a High-Density Genome Scan Atherosclerosis in Mice Is Not Affected by a Reduction in Tissue Factor Expression Atherosclerosis and the Lectin-like OXidized Low-Density Lipoprotein Scavenger Receptor Atherosclerosis and proteinase activation Apolipoprotein E Recycling Implications for Dyslipidemia and Atherosclerosis Anti-Atherosclerotic Effect of Amlodipine, Alone and in Combination With Atorvastatin, in APOE3-LeidenhCRP Transgenic Mice Altered expression balance of matrix metalloproteinases and their inhibitors in human carotid plaque disruption Age-related decrease in high-density lipoproteins antioxidant activity is due to an alteration in the PON1's free sulfhydyl groups A Negative Carotid Plaque Area Test Is Superior to Other Noninvasive Atherosclerosis Studies for Reducing the Likelihood of Having Underlying Significant Coronary Artery Disease 18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo Mycophenolate mofetil (MMF) Validation of Automatically Classified Magnetic Resonance Images for Carotid Plaque Compositional Analysis Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice Stabilization of Carotid Atheroma Assessed by Quantitative Ultrasound Analysis in Nonhypercholesterolemic Patients With Coronary Artery Disease Simultaneous expression of apolipoprotein B mRNA editing enzyme and scavenger receptor BI mediated by a therapeutic gene expression system Raised Plasma Soluble P-Selectin in Peripheral Arterial Occlusive Disease Enhances Leukocyte Adhesion Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes Nicotine Induces Proinflammatory Responses in Macrophages and the Aorta Leading to Acceleration of Atherosclerosis in Low-Density Lipoprotein Receptor-Mice Neointimal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty rats Macrophage Apolipoprotein E Reduces Atherosclerosis and Prevents Premature Death in Apolipoprotein E and Scavenger Receptor-Class BI Double-Knockout Mice Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women Lipoprotein-associated phospholipase A2 as a target of therapy Stimulation of Liver-Directed Cholesterol Flux in Mice by Novel N-Acetylgalactosamine-Terminated Glycolipids With High Affinity for the Asialoglycoprotein Receptor Low-Density Lipoprotein Cholesterol Determines Oxidative Stress and Endothelial Dysfunction in Saphenous Veins From Patients With Coronary Artery Disease Effects of Pioglitazone on Lipoproteins, Inflammatory Markers, and Adipokines in Nondiabetic Patients with Metabolic Syndrome Chemokines in Children With Heterozygous Familiar Hypercholesterolemia Linoleic acid increases monocyte deformation and adhesion to endothelium Lecithin cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease 25 year follow-up LDL size, total antioxidant status and oxidised LDL in normal human pregnancy a longitudinal study Lack of association between ADH3 polymorphism, alcohol intake, risk factors and carotid intima-media thickness In Vivo Intravascular Ultrasound-Derived Thin-Cap Fibroatheroma Detection Using Ultrasound Radiofrequency Data Analysis Homocysteine, circulating vascular cell adhesion molecule and carotid atherosclerosis in postmenopausal vegetarian women and omnivores High β-carotene and β-cryptoxanthin are associated with low pulse wave velocity Halting the progression of atherosclerosis with intensive lipid lowering Glucocorticoid Receptor Regulates ATP-Binding Cassette Transporter-A1 Expression and Apolipoprotein-Mediated Cholesterol Efflux From Macrophages Ferumoxtran-10-Enhanced MRI of the Hypercholesterolemic Rabbit Aorta Expression of Neutrophil Gelatinase-Associated Lipocalin in Atherosclerosis and Myocardial Infarction Estimating the fasting triglyceride concentration from the postprandial HDL-cholesterol and apolipoprotein CIII concentrations Epstein Barr virus specific T-cells generated from unstable human atherosclerotic lesions Effects of omega-3 fatty acids on coronary restenosis, intima–media thickness, and exercise tolerance Effects of Fluvastatin on the Carotid Arterial Media as Assessed by Integrated Backscatter Ultrasound Compared With Pulse-Wave Velocity Distinct Cellular Loci for the ABCA1-Dependent and ABCA1-Independent Lipid Efflux Mediated by Endogenous Apolipoprotein E Expression Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation Differential Expression of Chemokines, Risk of Stable Coronary Heart Disease, and Correlation with Established Cardiovascular Risk Markers Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women Cross-talk between dyslipidemia and renin–angiotensin system and the role of LOX-1 and MAPK in atherogenesis Coronary Artery Atherosclerosis Is Related to Reduced Regional Left Ventricular Function in Individuals Without History of Clinical Cardiovascular Disease Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells Automated Oscillometric Determination of the Ankle-Brachial Index Provides Accuracy Necessary for Office Practice Atorvastatin induces insulin sensitization in Zucker lean and fatty rats Atheroprotective Effects of High-Density Lipoprotein-Associated Lysosphingolipids Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake Ascending aortic blood pressure-derived indices are not correlated with the extent of coronary artery disease in patients with impaired left ventricular function Ankle-arm blood pressure index as a correlate of preclinical carotid atherosclerosis in elderly Japanese men Adipokines molecular links between obesity and atheroslcerosis Acute homocysteine administration does not elevate sympathetic nerve activity in rats A Common PCSK9 Haplotype, Encompassing the E670G Coding Single Nucleotide Polymorphism, Is a Novel Genetic Marker for Plasma LDL Cholesterol Levels and Severity of Coronary Atherosclerosis

Last Modified: 2006-07-30