Chemical biology

       　化学生物学是化学和生物学的交叉科学,是利用化学的理论、研究方法和手段来探索生物医学问题的科学，这无疑为医学生物学的发展开创了新的局面。同时，利用化学的角度来重新考虑医学生物学的问题，也带来了创新和发展的契机，这就使得化学生物学正迅速成为一个重要的交叉学科领域。为此CMBI特准备了关于Chemical biology的相关文献，供大家参考。更多文献，请用相关关键词通过CMBI文献查询获取。

• wide reach of enzymology-from bioorganic chemistry to chemical biology and beyond Mechanisms
  
• Tunneling of intermediates in enzyme-catalyzed reactions
  
• The mechanism of translation initiation codon selection in eukaryotes
  
• Simulations as analytical tools to understand protein aggregation and predict amyloid conformation
  
• Semisynthetic proteins in mechanistic studies
  
• Piecing together biomolecular self-assembly
  
• Nucleobase catalysis in ribozyme mechanism
  
• Nanoscale controlled self-assembled monolayers and quantum dots
  
• Isotope-edited IR spectroscopy for the study of membrane proteins
  
• Imaging molecular interactions in living cells by FRET microscopy
  
• Diffraction to study protein and peptide assemblies
  
• Coupling of the i-face and the active site of phospholipase A2 for interfacial activation
  
• Computational models for the prediction of polypeptide aggregation propensity
  
• Aspects of native proteins are retained in vacuum
  
• Analytical ultracentrifugation for the study of protein association and assembly
  
• AFM studies of the supramolecular assembly of bacterial photosynthetic core-complexes
  
• Stem cell neural differentiation
  
• Peptide-based fibrous biomaterials
  
• Novel materials for bone and cartilage regeneration
  
• Bioorthogonal noncovalent chemistry
  
• Applications of microfluidics in chemical biology
  
• Unnatural base pair systems for DNA-RNA-based biotechnology
  
• Synthetic glycobiology
  
• Strategies for the preparation of homogenous glycoproteins
  
• Stimulus responsive elastin biopolymers
  
• Sequencing single molecules of DNA
  
• Interactions between macromolecules and ions
  
• From therapeutic nucleic acids to redox hydrogels
  
• Expanding nucleic acid function in vitro and in vivo
  
• Electron-conducting redox hydrogels
  
• Building oligonucleotide therapeutics using non-natural chemistries
  
• Application of unnatural oligonucleotides to chemical modification of gene expression
  
• Where to begin-The mechanism of translation initiation codon selection in eukaryotes
  
• Tunneling of intermediates in enzyme-catalyzed reactions
  
• The wide reach of enzymology-from bioorganic chemistry to chemical biology and beyond Mechanisms
  
• Semisynthetic proteins in mechanistic studies
  
• Nucleobase catalysis in ribozyme mechanism
  
• IMP dehydrogenase-structural schizophrenia and an unusual base
  
• Evolution of enzyme superfamilies
  
• Enzyme promiscuity-evolutionary and mechanistic aspects
  
• Engineering of glycosidases and glycosyltransferases
  
• Coupling of the i-face and the active site of phospholipase A2 for interfacial activation
  
• Simulations as analytical tools to understand protein aggregation and predict amyloid conformation
  
• Nanoscale controlled self-assembled monolayers and quantum dots
  
• Isotope-edited IR spectroscopy for the study of membrane proteins
  
• Imaging molecular interactions in living cells by FRET microscopy
  
• Diffraction to study protein and peptide assemblies
  
• Computational models for the prediction of polypeptide aggregation propensity
  
• Aspects of native proteins are retained in vacuum
  
• Analytical ultracentrifugation for the study of protein association and assembly
  
• Analytical techniques-Piecing together biomolecular self-assembly
  
• AFM studies of the supramolecular assembly of bacterial photosynthetic core-complexes
  
• Pathogenic superoxide dismutase structure, folding, aggregation and turnover
  
• Mononuclear copper active-oxygen complexes
  
• Molybdenum and tungsten enzymes
  
• Microbial nickel metalloregulation
  
• Exploring new frontiers of nitrogenase structure and mechanism
  
• Evolution and unique bioenergetic mechanisms in oxygenic photosynthesis
  
• Bioinorganic chemistry
  
• The expanding roles of biocatalysis and biotransformation
  
• Recent advances in oxygenase-catalyzed biotransformations
  
• High-throughput screening of biocatalytic activity
  
• Breakdown of oligosaccharides by the process of elimination
  
• Biosensors and bioelectrochemistry
  
• Bioethanol
  
• Biocatalysis in pharmaceutical preparation and alteration