2006 诺贝尔医学生理学奖
        瑞典卡罗林斯卡医学院２日宣布，将２００６年诺贝尔生理学或医学奖授予美国科学家安德鲁·法尔和克雷格·梅洛，以表彰他们发现了ＲＮＡ（核糖核酸）干扰机制。
        诺贝尔奖评审委员会发布的公报说，法尔和梅洛获奖是因为他们“发现了控制遗传信息流动的基本机制”，这一机制为控制基因信息提供了基础性的依据。公报指出，ＲＮＡ干扰已被广泛用作研究基因功能的一种手段，并有望在未来帮助科学家开发出治疗疾病的新疗法。ＲＮＡ干扰机制的发现使得科学家可以对侵入细胞的病毒ＲＮＡ进行控制。诺贝尔奖评审委员会指出，ＲＮＡ干扰机制将来有望应用于临床医学和农业等众多领域，用来开发针对病毒感染、心血管疾病和癌症等的新疗法。
        CMBI特将两位获奖者背景、相关论文、网络链接资源以及RNAi关的文献等信息汇总于此，以供广大读者了解学习之用。 我们特别报道的 233、 182、 70、 41期都是RNAi相关的内容，请大家一并参考。
Medal

The Nobel Prize in Physiology or Medicine 2006

"for their discovery of RNA interference - gene silencing by double-stranded RNA"
Andrew Z. Fire Craig C. Mello
Photo: Stanford Photo: UMASS
Andrew Z. Fire Craig C. Mello
half 1/2 of the prize half 1/2 of the prize
USA USA
Stanford University School of Medicine
Stanford, CA, USA		 University of Massachusetts Medical School
Worcester, MA, USA
b. 1959 b. 1960
Andrew Z. Fire's page at Stanford School of Medicine Craig C. Mello's page at University of Massachusetts Medical School
Craig C. Mello's page at Howard Hughes Medical Institute

Andrew Z. Fire

  • Free in PMC Structural analysis of hyperperiodic DNA from Caenorhabditis elegans. Nucleic Acids Res. 2006 May 31;34(10):3057-66.
  • On the role of RNA amplification in dsRNA-triggered gene silencing. Cell. 2001 Nov 16;107(4):465-76.
  • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13;106(1):23-34.
  • Recognition and silencing of repeated DNA. Annu Rev Genet. 2000;34:187-204.
  • The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999 Oct 15;99(2):123-32.
  • Specific interference by ingested dsRNA. Nature. 1998 Oct 29;395(6705):854.
  • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998 Feb 19;391(6669):806-11.

    • Craig C. Mello

  • Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006 Jan 27;124(2):343-54.
  • Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28;436(7050):593-7.
  • Micromanaging insulin secretion. Nat Med. 2004 Dec;10(12):1297-8.
  • Revealing the world of RNA interference. Nature. 2004 Sep 16;431(7006):338-42.
  • MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans. Cell. 2002 Dec 27;111(7):991-1002.
  • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002 Jun 28;109(7):861-71.
  • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13;106(1):23-34.
  • Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000 Mar 31;287(5462):2494-7.
  • The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999 Oct 15;99(2):123-32.
  • WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999 Jun 11;97(6):717-26.
  • RNAi in C. elegans: soaking in the genome sequence. Science. 1998 Oct 16;282(5388):430-1.
  • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998 Feb 19;391(6669):806-11.

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