Alzheimer's Disease



肾素血管紧张素系统的新进展
肾素血管紧张素系统（renin-angiotensin system,RAS)由肾素把血管紧张素原转化为血管紧张素I（AngI），再在血管紧张素转化酶（ACE）的作用下转化为血管紧张素II和血管紧张素（1-7），然后通过和血管紧张素受体AT1和AT2发挥作用。在正常情况下，它对正常的心血管系统发育、维持心血管功能稳态、电解质和体液平衡以及血压调节起重要的作用，对心血管细胞的增殖、再塑、肥厚、纤维化、高血压、心肾功能不全等许多疾病的发病和治疗都具有重要意义。我们曾在73、115、129期做过相关报导。近年来，该领域又有大量研究进展。因此，CMBI特准备了关于肾素血管紧张素系统的新进展的特别报导，供研究参考。更多的文献资料，请用相关关键词‘cv-Agt’通过CMBI文献查询获取。
New fACEs to the renin-angiotensin system Pathophysiological regulation of the AT1-receptor and implications for vascular disease The use of angiotensin-converting enzyme inhibitors in patients undergoing coronary artery bypass graft surgery The tissue renin-angiotensin system and intracellular signalling Targeting angiotensin II type I receptors to reduce the risk of stroke in patients with hypertension Involvement of the renin-angiotensin system in migraine Angiotensin II-multitasking in the brain Signaling by the Angiotensin-Converting Enzyme Signaling by the Angiotensin-Converting Enzyme A review on pro-and anti-angiogenic factors as targets of clinical intervention Rethinking the renin-angiotensin system and its role in cardiovascular regulation Renal Protective Effects of the Renin-Angiotensin-Aldosterone System Blockade Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II pharmacol-Effect of angiotensin II type 1 receptor antagonism on endothelial function-role of bradykinin and nitric oxide Osmolarity-induced renin secretion from kidneys New fACEs to the Renin-Angiotensin System Membrane-associated zinc peptidase families-comparing ACE and ACE2 Long-lasting angiotensin type 1 receptor binding and protection by candesartan Intracrine renin and angiotensin II-a novel role in cardiovascular and renal cellular regulation Angiotensin receptor blockade with candesartan in heart failure Pancreatic Islet Renin Angiotensin System Essential Role of Smad3 in Angiotensin II–Induced Vascular Fibrosis Effects of Aldosterone on the Vasculature A different vision of the osmolar regulation of renin secretion Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins Angiotensin-sympathetic system interactions in cardiovascular and metabolic disease Angiotensin-converting enzyme-2-a molecular and cellular perspective Angiotensin-converting enzyme insertion-deletion polymorphism and systemic lupus erythematosus Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme II in the Heart and the Kidney Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells Angiotensin II type 2 receptor-mediated vasodilation ACE Polymorphisms ACE inhibitors and angiotensin receptor blockers in heart failure A story of two ACEs A Place in Our Hearts for the Lowly Angiotensin 1-7 Peptide Expression of Constitutively Active Angiotensin Receptors in the Rostral Ventrolateral Medulla Increases Blood Pressure Angiotensinogen Modulates Renal Vasculature Growth Angiotensin II Decreases the Renal MRI Blood Oxygenation Level-Dependent Signal Oxidant Stress and Blood Pressure Responses to Angiotensin II Administration in Rats Fed Varying Salt Diets Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice ACE Polymorphisms Signaling by the Angiotensin-Converting Enzyme Essential Role of Smad3 in Angiotensin II-Induced Vascular Fibrosis Angiotensin II acutely decreases myocardial stiffness a novel AT1, PKC and Na+H+ exchanger-mediated effect Evidence Supporting a Functional Role for Intracellular Renin in the Brain. 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Advanced Glycation End Products Activate a Chymase-Dependent Angiotensin II-Generating Pathway in Diabetic Complications. A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species. The hematopoietic system Pre-and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade Activation of AMP-Activated Protein Kinase Enhances Angiotensin II-Induced Proliferation in Cardiac Fibroblasts Role of Angiotensin Type-1 and Angiotensin Type-2 Receptors in the Expression of Vascular Integrins in Angiotensin II-Infused Rats The Angiotensin II Type 2 Receptor Causes Constitutive Growth of Cardiomyocytes and Does Not Antagonize Angiotensin II Type 1 Receptor-Mediated Hypertrophy Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-κB and AP-1 in vascular smooth muscle cells Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats Body Mass Index and Angiotensin-Dependent Control of the Renal Circulation in Healthy Humans Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei Local renin–angiotensin–aldosterone systems and the pathogenesis and treatment of cardiovascular disease Hydrolysis of Angiotensin Peptides by Human Angiotensin I-Converting Enzyme and the Resensitization of B2 Kinin Receptors Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition Constrictor and Dilator Effects of Angiotensin II on Cerebral Arterioles Angiotensin II Type 1 Receptor Agonistic Antibodies Reflect Fundamental Alterations in the Uteroplacental Vasculature Update on the role of the AT2 receptor Role of Natriuretic Peptide Receptor Guanylyl Cyclase-A in Myocardial Infarction Evaluated Using Genetically Engineered Mice Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats Blockade of angiotensin II provides additional benefits in hypertension-and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects Angiotensin-Converting Enzyme 2 (ACE2) and ACE Activities Display Tissue-Specific Sensitivity to Undernutrition-Programmed Hypertension in the Adult Rat Renin-Angiotensin System Intervention to Prevent In-Stent Renin, Prorenin and the Putative (Pro)renin Receptor Renin, Prorenin and the Putative (Pro)renin Receptor Lipid Accumulation and Transforming Growth Factor-[beta] Upregulation in the Kidneys of Rats Administered Angiotensin II Interaction of Angiotensin II Type 1 and D5 Dopamine Receptors in Renal Proximal Tubule Cells Dual Pathways for Nuclear Factor [kappa]B Activation by Angiotensin II in Vascular Smooth Muscle Chronic At1 Receptor Blockade Alters the Mechanisms Mediating Hypoxic Dilation in Middle Cerebral Arteries Angiotensin-Converting Enzyme Inhibition Increases Basal Vascular Tissue Plasminogen Activator Release in Women But Not in Men Angiotensin-converting enzyme as a GPIase Angiotensin Type 2 Receptor Is Expressed in Murine Atherosclerotic Lesions and Modulates Lesion Evolution Working outside the system-an update on the unconventional behavior of the renin-angiotensin system components Addition of an angiotensin receptor blocker to full-dose ACE-inhibition The Mineralocorticoid Receptor and Oxidative Stress The Inhibitory Effects of Sevoflurane on Angiotensin II-Induced, p4442 Mitogen-Activated Protein Kinase-Mediated Contraction of Rat Aortic Smooth Muscle The Endothelium-Dependent Vasodilator Effect of the Nonpeptide Ang(1-7) Mimic AVE 0991 Is Abolished in the Aorta of Mas-Knockout Mice. 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Angiotensin II Plays an Important Role in Maintaining Blood Pressure in Postmenopausal Women Receiving Hormone Replacement Therapy Adrenal Angiotensin Origin and Site of Generation Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension. Renin-angiotensin systemThe regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet. Deletion of Angiotensin II Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E-Null Mice. Complement Activation in Angiotensin II–Induced Organ Damage Angiotensin II modulates renal sympathetic neurotransmission through nitric oxide in AT2 receptor knockout mice. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1–7) expression in the aorta of spontaneously hypertensive rats Aldosterone and Angiotensin II Synergistically Induce Mitogenic Response in Vascular Smooth Muscle Cells A crucial role of angiotensin converting enzyme 2 (ACE2)in SARS coronavirus–induced lung injury Specific Properties and Effect of Perindopril in Controlling the Renin–Angiotensin System Renin-Angiotensin System Modulation How to Explain the Differences Between Renin Angiotensin System Modulators The Renin-Angiotensin System hp-Evidence for Benefits of Perindopril in Hypertension and Its Complications genetics-Mutations in genes in the renin-angiotensin system Stimulation of Endothelial Progenitor Cells Signal-Crosstalk Between RhoROCK and c-Jun NH2-Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II Sex Difference in Vascular Injury and the Vasoprotective Effect of Valsartan Are Related to Differential AT2 Receptor Expression Genotypic interactions of renin–angiotensin system genes in myocardial infarction Regulation of Discoidin Domain Receptor 2 by Cyclic Mechanical Stretch in Cultured Rat Vascular Smooth Muscle Cells Regulation of ACE2 and ANG-(1–7) in the aorta Oxidative Stress Mediates Angiotensin II–Dependent Stimulation of Sympathetic Nerve Activity Local Renal Aldosterone System and Its Regulation by Salt, Diabetes, and Angiotensin II Type 1 Receptor Mutations in genes in the renin-angiotensin system Functional evidence that in the cardiovascular system AT1 angiotensin II receptors are AT1B prejunctionally and AT1A postjunctionally Detection of Angiotensin II in Supernatants of Stimulated Mononuclear Leukocytes by Matrix-Assisted Laser Desorption Ionization Time-of-FlightTime-of-Flight Mass Analysis Combined Angiotensin II Type 1 and Type 2 Receptor Blockade on Vascular Remodeling and Matrix Metalloproteinases in Resistance Arteries Caveolin-1 Is Essential for Activation of Rac1 and NAD(P)H Oxidase After Angiotensin II Type 1 Receptor Stimulation in Vascular Smooth Muscle Cells Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1–7) expression Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein–Independent Signals Renin-Dependent Hypertension Caused by Nonfocal Stenotic Aberrant Renal Arteries Protein kinase C epsilon mediates angiotensin II-induced activation of 1-integrins in cardiac fibroblasts Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3K Microvascular Effects of Aldosterone and Angiotensin Type 2 Receptors Impaired Heart Rate Baroreflex in Older Rats Role of Endogenous Angiotensin-(1–7) at the Nucleus Tractus Solitarii Glucose-6 Phosphate Dehydrogenase Deficiency Decreases the Vascular Response to Angiotensin II Genetic Deletion of the p66Shc Adaptor Protein Protects From Angiotensin II–Induced Myocardial Damage Functional evidence that in the cardiovascular system AT1 angiotensin II receptors are AT1B prejunctionally and AT1A postjunctionally Electrophysiological Properties of Rostral Ventrolateral Medulla Neurons in Angiotensin II 1a Receptor Knockout Mice Differing Effects of Mineralocorticoid Receptor–Dependent and –Independent Potassium-Sparing Diuretics on Fibrinolytic Balance Blockade of Endogenous Angiotensin-(1–7) in the Hypothalamic Paraventricular Nucleus Reduces Renal Sympathetic Tone Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells Angiotensin II and cell-matrix adhesion Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats Six Truisms Concerning ACE and the Renin-Angiotensin System Educed From the Genetic Analysis of Mice Renin-Angiotensin System Modulates Oxidative Stress-Induced Endothelial Cell Apoptosis in Rats Mechanisms of Reactive Oxygen Species-Dependent Downregulation of Insulin Receptor Substrate-1 by Angiotensin II Contribution of Arachidonic Acid Metabolites Derived Via Cytochrome P4504A to Angiotensin II-Induced Neointimal Growth Angiotensin IV Activates the Nuclear Transcription Factor-[kappa]B and Related Proinflammatory Genes in Vascular Smooth Muscle Cells Angiotensin II Increases H+-ATPase B1 Subunit Expression in Medullary Collecting Ducts Angiotensin II Enhances Interleukin-18 Mediated Inflammatory Gene Expression in Vascular Smooth Muscle Cells Angiotensin II and cell-matrix adhesion-PKC is essential A New Cellular Signaling Mechanism for Angiotensin II Activation of NF-[kappa]B Transcriptional Regulation of Renin--- Selective Angiotensin-Converting Enzyme C-Domain Inhibition Is Sufficient to Prevent Angiotensin I–Induced Vasoconstriction Role of NAD(P)H Oxidase-and Mitochondria-Derived Reactive Oxygen Species in Cardioprotection of Ischemic Reperfusion Injury by Angiotensin II. 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Discordant Angiotensin and Blood Pressure Responses to Orthostasis in Healthy Postmenopausal Women AT1 receptors and L-type calcium channels Angiotensin System Inhibitors in a General Surgical Population Angiotensin II-Dependent Chronic Hypertension and Cardiac Hypertrophy Are Unaffected by gp91phox-Containing NADPH Oxidase Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization Angiotensin II Type 2 Receptor-Mediated Gene Expression Profiling in Human Coronary Artery Endothelial Cells Renin-Angiotensin System Intervention to Prevent In-Stent Restenosis An Unclosed Chapter Effects of Angiotensin Type-1 Receptor Antagonism on Small Artery Function in Patients With Type 2 Diabetes Mellitus Pharmacological Inhibition and Genetic Deficiency of Plasminogen Activator Inhibitor-1 Attenuates Angiotensin IISalt-Induced Aortic Remodeling Mechanisms Underlying the Endothelium-Independent Relaxation Induced by Angiotensin II in Rat Aorta 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Dysfunction Associated With Insulin Resistance Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion Endogenous Angiotensin and Pressure Modulate Brain Angiotensinogen and AT1A mRNA Expression Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK-a mechanism for activation of latent TGF-1 Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells Alterations in Sympathetic Ganglionic Transmission in Response to Angiotensin II in (mRen2)27 Transgenic Rats Aldosterone enhances renin gene expression in juxtaglomerular cells Tumor Necrosis Factor-Activates NFB to Inhibit Renin Transcription by Targeting cAMP-responsive Element Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site Role of metabolism and receptor responsiveness in the attenuated responses to Angiotensin II in mice compared to rats PLA2-PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1–7)-stimulated Na+-ATPase activity of the proximal tubule Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1 Can Angiotensin II Type 2 Receptors Have Deleterious Effects in Cardiovascular Disease Activation of a local tissue angiotensin system in podocytes by mechanical strain 1 ACE, ACE Inhibitors, and Other JNK

Last Modified: 2006-10-29