MiRNA与肿瘤



MiRNA与肿瘤
MicroRNA是一类约有18-24个核苷酸的非编码的小RNA分子，它在基因转录后水平上，通过与靶mRNA (信使RNA)互补结合，对基因的表达起负调节作用或基因沉默。MicroRNA广泛存在于真核生物中，在物种间具有高度的保守性、时序性和组织特异性。MicroRNA的广泛存在与进化保守性，暗示着它在生命活动中具有必不可少的调节作用，对基因表达、生长发育和行为等都具有十分广泛和深远的效应。近年来，很多文献报道microRNA的异常表达与特定的肿瘤具有相关性。此次CMBI特准备了近年来MiRNA与肿瘤相关文献，供大家参考。更多文献，请用相关关键词通过CMBI文献查询获取。
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Last Modified: 2007-12-11