干细胞进展



干细胞进展
本月20号，Cell杂志发表了一篇由日本京都大学的论文，宣布成功把人体皮肤细胞改造成类似胚胎干细胞的多能细胞，并且由此诱导分化出神经细胞和心肌细胞。同一天，Science杂志也发表一篇美国威斯康星大学的论文，报告了类似的结果，甚至两个小组的研究方法和原理都大同小异。学界评价这一突破为生物科学的“里程碑”，这一成果不仅为干细胞的研究开辟了新的途径，更为研究疾病机理、药物筛选、疾病治疗特别是个性化治疗提供了广阔的前景，在进一步解决一些安全问题之后甚至可以用来进行细胞移植。此次CMBI特准备了两个研究小组各自发表的系列文章以及今年以来干细胞相关文献，供大家参考。之前CMBI在特别报道的266、214、136、120、113、109、39、10期做过干细胞相关的报道。更多文献，请用相关关键词通过CMBI文献查询获取。
京都大学发表的系列论文及相关评论 Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 2007 Nov 20. Reprogramming somatic cells towards pluripotency by defined factors. Curr Opin Biotechnol. 2007 Oct;18(5):467-73. Generation of germline-competent induced pluripotent stem cells. Nature. 2007 Jul 19;448(7151):313-7. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. Pluripotency redux-advances in stem-cell research. N Engl J Med. 2007 Oct 11;357(15):1469-72. 威斯康星大学发表的系列论文及相关评论 Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 2007 Jan;17(1):42-9. Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells. 2006 Mar;24(3):568-74 Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol. 2006 Feb;24(2):185-7 Field Leaps Forward With New Stem Cell Advances. Science. 2007 Nov 23;318(5854):1224-5. 干细胞进展 Connecting the paths in plant stem cell regulation Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways Xeno-free derivation and culture of human embryonic stem cells A Scientist's View of the Ethics of Human Embryonic Stem Cell Research Adult stem cell therapy Aptamer-based strategies for stem cell research Bioprocessing of embryonic stem cells for drug discovery Blood stem cells and non-hematological clinical practice Breakdown of the Potentiality Principle and Its Impact on Global Stem Cell Research Can we develop ethically universal embryonic stem-cell lines Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes. Cell therapy and the safety of embryonic stem cell-derived grafts cell-Functional properties and intracellular signaling of CCN1-Cyr61 Controlling neural stem cell state and fate in vivo and in vitro with biomaterials Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Dendritic Cell Development in the Context of the Spleen Microenvironment Differences between human embryonic stem cell lines Does Government Regulation Inhibit Embryonic Stem Cell Research and Can It Be Effective Does N-Cadherin Regulate Interaction of Hematopoietic Stem Cells with Their Niches drug discovery-Embryonic stem cells as a source of models for drug discovery Embryonic stem-cell culture as a tool for developmental cell biology Epithelial stem cells- Ethical Standards for Human-to-Animal Chimera Experiments in Stem Cell Research Exploiting the properties of adult stem cells for the treatment of disease eye-Niche regulation of corneal epithelial stem cells Facilitating cells-novel promoters of stem cell alloengraftment and donor-specific transplantation tolerance Feasibility and safety of autotransplants with noncryopreserved marrow or peripheral blood stem cells FoxO Transcription Factors and Stem Cell Homeostasis Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool From the laboratory bench to the patient's bedside-An update on clinical trials with mesenchymal stem cells Germ cell-Epigenetic decisions in mammalian germ cells Germ cell-Gametes from embryonic stem cells Germ cell-Germ cell specification in mice Germ cell-Germ versus soma decisions Germ cell-Male and female Drosophila germline stem cells Germ cell-Male germline stem cells Germ cellpiRNAs in the germ line Germ cell-sexual identity. The germ cell's perspective gi-In vitro differentiation of hepatic progenitor cells from mouse embryonic stem cells induced by sodium butyrate gi-Stem cells in the adult pancreas and liver gi-Towards stem-cell therapy in the endocrine pancreas Human mesenchymal stem cells at the single-cell level imm-T cell therapies following hematopoietic stem cell transplantation Integrating epitope data into the emerging web of biomedical knowledge resources Lessons from musculoskeletal stem cell research Limbal epithelial stem cell therapy Lung Cancer and Lung Stem Cells Making Stem Cell Lines Suitable for Transplantation Male Germline Stem Cells MAPK-ing Out the Pathways in Lung Stem Cell Regulation Nanog and transcriptional networks in embryonic stem cell New directions in the genomics of allogeneic hematopoietic stem cell transplantation.- Prediction and Testing of Novel Transcriptional Networks Regulating Embryonic Stem Cell Self-Renewal and Commitment Progeria of stem cells proteome-Embryonic stem cell proteomics- proteome-The characterization of stem cell proteomes proteome-Trends in Stem Cell Proteomics Regulating the Notch pathway in embryonic, adult and old stem cells RNA-An effective method for adenoviral-mediated delivery of small interfering RNA into mesenchymal stem cells RUNX regulates stem cell proliferation and differentiation Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation Stem Cell Epigenetics Stem Cells and the Rate of Living Stem cells and their niche Stem cells in cell transplantation Stem Cells, Aging, Niche, Adhesion and Cdc42 Stem-cell niches Stem-cell niches- Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells Symposium in Stem Cell Repair and Regeneration Telomere Biology in Normal and Leukemic Hematopoietic Stem Cells The key role of adult stem cells-therapeutic perspectives The Mother of All Stem Cells The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myeloid leukemia in children The role of noggin in human mesenchymal stem cell differentiation The therapeutic potential of embryonic stem cells-A focus on stem cell stability Therapeutic targeting of a stem cell niche Treatment of adenovirus disease in stem cell transplant recipients with cidofovir Tumor suppressor dosage regulates stem cell dynamics during aging UC blood hematopoietic stem cells and therapeutic angiogenesis Stem-cell niches-nursery rhymes across kingdoms Mesenchymal stem cells-a new strategy for immunosuppression Towards stem-cell therapy in the endocrine pancreas cv-Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo genetics-Epigenetic signatures of stem-cell identity Molecular profiling of stem cells Stem cell enrichment approaches The role of noggin in human mesenchymal stem cell differentiation blood-Niche-to-niche migration of bone-marrow-derived cells Controlled Clinical Trials on the Use of Ursodeoxycholic Acid for the Prevention of Hepatic Veno-occlusive Disease in Hematopoietic Stem Cell Transplantation Epithelial Stem Cells-Turning over New Leaves Human Embryonic Stem Cell Research New Directions in the Genomics of Allogeneic Hematopoietic Stem Cell Transplantation Stem cells from the womb the complexity of stem-cell diseases Autologous and allogeneic stem cell transplantation for myelodysplastic syndrome New Directions in the Genomics of Allogeneic Hematopoietic Stem Cell Transplantation The Proteasome Restricts Permissive Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells urology-Stem Cells for Regeneration of Urological Structures

Last Modified: 2007-11-26