MiRNAs与心血管疾病



MiRNAs与心血管疾病
MiRNAs是一类约有18-24个核苷酸的非编码小RNA分子，它可在基因转录后水平上，通过与靶mRNA互补结合，调节基因的表达，进而调节机体的基本生物学过程，包括细胞增殖、凋亡、应激、免疫、生长和发育，它不仅在肿瘤的发生中有重要意义(见特别报道327期)，亦与心血管的功能调节、疾病发生和疾病防治有着密切的关系，成为心血管研究中的一个新的热点和亮点。这里搜集了一些MiRNAs与心血管相关的综述论文，供大家参考。更多文献，请用相关关键词通过CMBI文献查询
MicroRNA and cardiac pathologies MicroRNAs Control Gene Expression The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure Toward MicroRNA–Based Therapeutics for Heart Disease basic mechanisms and transcriptional regulatory networks for cell fate determination Regulation of MicroRNA by Antagomirs-A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function Control of cardiac excitability by microRNAs novel regulators in cardiac development and disease Role of microRNAs in vascular diseases, inflammation, and angiogenesis MicroRNA Expression in the Blood and Brain of Rats Subjected to Transient Focal Ischemia by Middle Cerebral Artery Occlusion MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation MicroRNA miR-133 Represses HERG K+ Channel Expression Contributing to QT Prolongation in Diabetic Hearts MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule MicroRNA-21 Increases Aldosterone Secretion A microRNA component of the hypoxic response STKE-miRNAs Have Big Effects in the Heart MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Targeting microRNA expression to regulate angiogenesis altered miRNA exp in heart miRNA in skeletal and cardiac mus miRNAs put their sig on the heart MicroRNA -126 regulates endothelial expression of vascular cell adhesion molecule expression in Duchenne and Becker muscular dystrophy MicroRNA Expression in the Blood and Brain of Rats Subjected to Transient Focal Ischemia by Middle Cerebral Artery Occlusion Are Aberrantly Expressed in Hypertrophic Heart Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy miR-1-2 Gets to the Heart of the Matter Emerging Role of MicroRNAs in Cardiovascular Biology Targeting microRNA expression to regulate angiogenesis MicroRNA Expression Signature and Antisense-of MicroRNA in Neointimal MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling MicroRNA-143 Regulates Adipocyte Differentiation MicroRNA-155 Regulates Human Angiotensin II Type 1 Receptor Expression in Fibroblasts A signature pattern of stress-responsive microRNAs that can evoke hypertrophy and heart failure Angiotensin II Receptor +1166 A-C Polymorphism Attenuates MicroRNA-155 Binding Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA Distinctive patterns of microRNA expression in primary muscular disorders Emerging Role of MicroRNAs in Cardiovascular Biology MicroRNAs in the Human Heart Muscle-specific microRNA miR-206 promotes muscle differentiation muscle-specific microRNAs produce opposing effects on apoptosis by HSP in cardiomyocytes Myogenic factors that regulate expression of muscle-specific microRNAs Regulation of endothelial nitric oxide synthase by small RNA Role of Dicer and Drosha for Endothelial MicroRNA Expression and Angiogenesis Signature of Hypoxia Play an Essential Role in the Development of Cardiac Hypertrophy powerful new regulators of heart disease and provocative therapeutic targets Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation Peroxisome Proliferator-Activated Receptor Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation Review Focus on MicroRNA and Cardiovascular Function

Last Modified: 2008-11-20