Clinical Immunology:
Self-Assessment Questions

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1) Severe combined immunodeficiency:

(a) is an X-linked hereditary immunodeficiency.
True False

(b) is associated with low levels of serum complement factors.
True False

(c) results from a failure of the 3rd and 4th pharyngeal pouches to form fully.
True False

(d) involves defects of both humoral and cell mediated immunity.
True False

(e) is best treated by bone marrow transplantation.
True False

2) Chronic granulomatous disease:

(a) affects B cells, T cells and macrophages.
True False

(b) rarely presents before adulthood.
True False

(c) affects male more than females.
True False

(d) is characterised by a lack of intracellular killing of phagocytosed bacteria.
True False

(e) is usually accompanied by polymorphonuclear leukocytosis.
True False

3) Defective T cell function is characteristic of:

(a) X-linked agammaglobulinaemia
True False

(b) di George syndrome
True False

(c) severe combined immunodeficiency
True False

(d) infection with HIV
True False

(e) sarcoidosis
True False

4) Which of the following statements are true:

(a) HIV infection is associated with selective depletion of CD4+ T cells.
True False

(b) IgA deficiency should be treated by immunoglobulin replacement therapy.
True False

(c) X-linked agammaglobulinaemia is commoner in girls than boys.
True False

(d) intravenous immunoglobulin therapy is effective in T cell immunodeficiencies.
True False

(e) primary immunodeficiencies are more common than secondary immunodeficiencies.
True False

5) In complement deficiencies:

(a) hereditary angioedema is caused by acongenital deficiency of the C1 inhibitor.
True False

(b) deficiencies of the 3rd complement component (C3) are associated with recurrent viral infections.
True False

(c) deficiencies of the late complement components (C5-C9) are associated with recurrent infections with gonococci or meningococci.
True False

(d) in patients with C1, C4 or C2 deficiency, IgM and IgG antibodies bound to micro-organisms can activate the alternative pathway, and so compensate for the defect.
True False

(e) properdin deficiency is commoner in males than females.
True False

DISCLAIMER          © Department of Microbiology and Immunology, 1996.