Innate and Adaptive Immunity:
Self-Assessment Questions

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1) Which of the following prevent microbial invasion of body surfaces?

(a) Mucus secretion.
True False

(b) Polymorphonuclear leukocytes.
True False

(c) Epithelial integrity.
True False

(d) Mucociliary clearance
True False

(e) Urine flow.
True False

2) Which of the following predispose to microbial invasion?

(a) Urinary obstruction.
True False

(b) Ciliary dyskinesia.
True False

(c) Cystic fibrosis.
True False

(d) Skin ulceration.
True False

(e) Neutrophil deficiency.
True False

3) Which of the following are characteristics of innate immunity?

(a) Efficiency increases on subsequent exposure to the same organism.
True False

(b) Involves lymphocytes.
True False

(c) Is present from birth.
True False

(d) Includes opsonisation.
True False

(e) May involve the acute inflammatory response.
True False

4) Regarding acquired (adaptive) immunity, which are the following are true?

(a) Immunological recognition is an important component.
True False

(b) Antibody is produced by T cells.
True False

(c) Recognition of antigen by B cells is mediated by antibody.
True False

(d) Antibodies produced in response to infection recognise more than one epitope on the surface of the invading micro-organisms.
True False

(e) Elimination of intracellular micro-organisms is dependent on antibody.
True False

5) Which of the following features of the immune system is present at birth?

(a) Cell-mediated immunity to micro-organisms.
True False

(b) Complement.
True False

(c) Serum immunoglobulin.
True False

(d) Inflammatory response.
True False

(e) Neutrophils.
True False

6) T lymphocytes:

(a) Are not derived from bone marrow precursors.
True False

(b) Produce antibodies.
True False

(c) Secrete lymphokines.
True False

(d) Undergo maturation in the thymus gland.
True False

(e) Can be distinguished from B lymphocytes on routine light microscopy.
True False

7) Within lymph nodes:

(a) B lymphocytes predominate in the paracortex.
True False

(b) Primary follicles are aggregates of B cells.
True False

(c) Secondary follicles develop following antigenic stimulation.
True False

(d) Lymph flows from the hilum of the node outwards to the marginal sinus.
True False

(e) The medulla is rich in plasma cells.
True False

8) Concerning secondary lymphoid follicles:

(a) The cells of the follicle centre are exclusively B cells.
True False

(b) Immunoblasts are numerous.
True False

(c) A mantle zone surrounds the follicle centre.
True False

(d) Centrocytes result from mitotic division of centroblasts.
True False

(e) Antigen presenting cells are present.
True False

9) Mucosa associated lymphoid tissue:

(a) Is found exclusively in the GI tract.
True False

(b) Increases with age in the stomach.
True False

(c) Consists entirely of B cells.
True False

(d) Is important in the response to luminal antigen.
True False

(e) Includes cells which are able to home back to their mucosal site.
True False

10) Lymphocyte recirculation:

(a) Occurs between lymphoid tissues only.
True False

(b) Depends on adhesion molecule expression by endothelium.
True False

(c) Involves substances known as addressins.
True False

(d) Is a feature of T cells and not B cells.
True False

(e) Cannot occur between the lymph nodes and spleen.
True False

DISCLAIMER          © Department of Microbiology and Immunology, 1996.